We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.

Principal Investigator Matthias Meier
Bioengineering and Microfluidics

Research

Oliver Bruns' research is dedicated to the development of excellent techniques for biomedical imaging. The advancement of new targeted contrast agents and novel imaging modalities will pave the way for personalized therapy and high precision treatments in the near future. Imaging in the short-wave infrared region (SWIR) is a new technology for biomedical applications. It provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. In this wavelength range tissues become translucent. Recent progress in detection technology and the development of probes demonstrated that, in principal, SWIR imaging enables applications which were previously not feasible with any other technique. These advantages will enable new capabilities in preclinical imaging. Most SWIR imaging setups so far are used for proof of principal demonstrations only. 

Human fat tissue has evolved to serve as a major energy reserve. An imbalance between energy intake and expenditure leads to an expansion of adipose tissue and degeneration of the endocrine function of the pancreas. Maintenance of this energy imbalance over longer times leads to obesity and metabolic disorders such as type 2 diabetes, for which clinical cures are not yet available. 

Our research project aims to develop and use pancreatic and adipose tissue models outside organisms in sizes of micrometers for studying the differentiation of human inducible pluripotent stem cells (hiPSCs) into functional tissue. For assembly of so called organoids, we combine microfluidic chip technologies with quantitative bioanalytics. In particular, the integration of organoids on microfluidic chip platforms is exploited in our lab to dynamically control their chemical, cell architectural, and mechanical microenvironment of hiPSCs. With novel single cell resolution in situ detection systems, we aim to reveal, which microenvironmental stem cell niche factors are required to differentiate hiPSCs into metabolic responsive cells, communication pathways between organs, and the importance of cell heterogeneity in organs for their proper function.
 

Our key questions

Upon combining engineering and biology approaches, we want to understand mechanistically the role of natural stem cell niches, determine how to simulate them under laboratory conditions and finally provide patient-specific, clinically relevant information for developing new cell-based treatments for obesity and diabetes.

Group members focus to find solutions for the following four key questions:

  • Does a dynamic chemical microenvironment changes cell lineage decisions during the development of the human adipose and pancreatic tissue?  (Keyword: Chemical Programming by Microfluidics)
  • Can we induce and resolve cell heterogeneity in pancreatic organoids? (Keyword: Single Cell Protein Interaction Profiling)
  • Can we resolve cell heterogeneity with high spatial analysis in organoids on chip? (Keyword: Spatial Protein Interaction Profiling)
  • How to assemble functional adipocytes and/or pancreas organoids on chip?  (Keyword: Organ-on-Chip)

Dr. Matthias Meier

Principal Investigator, Bioengineering and Microfluidics

Matthias Meier is a German biophysicist who received his PhD from the University of Basel in Switzerland in 2006. In 2008 he was awarded with the Feodor-Lynen postdoctoral fellowship from the Alexander von Humboldt Foundation and worked 4 years with Steven Quake at Stanford University. With help of an Emmy-Noether-Fellowship from the German Research Foundation he returned to Europe and established an independent research group at the Microsystem Engineering department of the University of Freiburg. In 2017 Dr. Meier received the ERC Consolidator grant for performing research in medical engineering field of Organ-on-Chips. In 2018 Matthias Meier joined the Helmholtz Pioneer Campus.

Factsheet

Dr. Matthias Meier

Positions and Career

2018 - present
Principal Investigator at Helmholtz Pioneer Campus, Helmholtz Zentrum München, Germany

2012 - 2018
Independent Research Group Leader (DFG Emmy-Noether Fellow) at IMTEK, University of Freiburg, Germany

2009 - 2011
Postdoc at Stanford University, Laboratory of Professor Stephen Quake, USA

2008 - 2009
Postdoc at University of Chicago, Laboratory of Professor Rustem Ismagilov, USA

 

1998 – 2004
Biochemistry, University of Regensburg, Germany

2003 - 2004
Diploma in Biophysics, University of Regensburg, Germany
Supervisor: Prof. Dr. Eike Brunner

2004 - 2008
PhD in Biophysics / University of Basel, Szitzerland
Supervisor: Prof. Dr. Joachim Seelig

 

Invited Lectures

03/2016
Institute de Gennes, Synergy Microfluidics & Biology, Paris, France

10/2015
MicroTas, South Korea (1 PhD student talk)  

04/2015
W2 Professorship application, Westfälische-Wilhelms-Universität, Münster, Germany

10/2014
MicroTas, San Antonio, USA (2 Talks from my PhD students) 

09/2014
DFG (German Research Foundation), Biophysical Meeting, Germany

06/2014
ISMB Meeting, Boston, USA

05/2014
DKFZ, Synthetic Biology Meeting, Heidelberg, Germany

04/2014
W2 Professorship application (2nd ranked), Düsseldorf, Germany

10/2013
MicroTas, Freiburg (1 PhD student talk), Germany

03/2013
Dachema, Synthetic Biology Conference, Germany

02/2010 & 07/2011
Gordon Conference, Biological Microfluidics, Italy   

12/2009
EMBL, Group Leader application (2nd ranked), Germany

 

2014 - present
Member of the German Biophysical Society

2014 - present
Technical Board Member of MicroTas

 

2018 - 2023
European Research Council (ERC) - Consolidator
Consolidator Grant “MicroAdiPS Chip: Micro Fat Tissue on Chip

 

Lab Manager

Alina Platen

E-Mail

Postdocs

Dr. Scott Atwell

E-Mail

Research focus: Organ-on-Chip

Dr. Tihomir Georgiev

E-Mail

Research focus: Chemical programming by microfluidics

Dr. Michel Moussus

E-Mail

Research focus: Organ-on-Chip

PhD Students

Jessi Ardila Riveros

E-Mail

Research focus: Chemical programming by microfluidics

Nina Compera

E-Mail

Research focus: Organ-on-Chip

Daniel Kokotek

E-Mail

Research focus: Spatial protein interaction profiling

Simon Rosowski

E-Mail

Research focus: Single cell protein interaction profiling

Sandra Wiedenmann

E-Mail

Research focus: Organ-on-Chip

Julius Wiener

E-Mail

Research focus: Single cell protein interaction profiling

Johannes Wirth

E-Mail

Research focus: Spatial protein interaction profiling

Tin Wang Wong

Research focus: Organ-on-Chip

Selected Publications

MHC class II proteins mediate cross-species entry of bat influenza viruses.

Karakus U, Thamamongood T, Ciminski K, Ran W, Günther SC, Pohl MO, Eletto D, Jeney C, Hoffmann D, Reiche S, Schinköthe J, Ulrich R, Wiener J, Hayes MGB, Chang MW, Hunziker A, Yángüez E, Aydillo T, Krammer F, Oderbolz J, Meier M, Oxenius A,  Halenius A, Zimmer G, Benner C, Hale BG, García-Sastre A, Beer M, Schwemmle M, Stertz S.
Nature. 2019 Mar;567(7746):109-112. doi: 10.1038/s41586-019-0955-3.

More Details

Genetic Code Expansion Method for Temporal Labeling of Endogenously Expressed Proteins.

Schneider N, Gäbelein C, Wiener J, Georgiev T, Gobet N, Weber W, Meier M.
ACS Chem Biol. 2018 Nov 16;13(11):3049-3053. doi: 10.1021/acschembio.8b00594.

More Details

Rapid spheroid clearing on a microfluidic chip.

Silva Santisteban T, Rabajania O, Kalinina I, Robinson S, Meier M.
Lab Chip. 2017 Dec 19;18(1):153-161. doi: 10.1039/c7lc01114h.

More Details

In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip.

Wu X, Schneider N, Platen A, Mitra I, Blazek M, Zengerle R, Schüle R, Meier M.
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4143-50. doi: 10.1073/pnas.1601207113.

More Details

Analysis of fast protein phosphorylation kinetics in single cells on a microfluidic chip.

Blazek M, Santisteban TS, Zengerle R, Meier M.
Lab Chip. 2015 Feb 7;15(3):726-34. doi: 10.1039/c4lc00797b.

More Details

Proximity ligation assay for high-content profiling of cell signaling pathways on a microfluidic chip.

Blazek M, Betz C, Hall MN, Reth M, Zengerle R, Meier M.
Mol Cell Proteomics. 2013 Dec;12(12):3898-907. doi: 10.1074/mcp.M113.032821.

More Details

Contact us

HPC contact Meier

Contact

 

Helmholtz Pioneer Campus
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Ingolstädter Landstr. 1
85764 Neuherberg
Germany