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Principal Investigator Ryan Remedios
Autonomous and Autonomic Systems

Research

Ryan Remedios' team is interested in harnessing the knowledge of nervous system control over physiology and behaviour, to improve the quality of life and provide dignity to demographics afflicted by aging, disease and illness. My interdisciplinary laboratory is comprised of bright, young scientists with backgrounds in medicine, engineering, physics, veterinary medicine, etc., focused on treating human diseases, through the development of new technologies and the identification of new molecular targets. Towards this goal my laboratory is exploring autonomic and autonomous system utility and control by discovering the underlying principles that stabilise nervous system function.
 

Projects

Autonomous Systems

The brain possesses the fantastic property of being able to learn from a single event or incident. This is remarkably different from how the majority of “smart” machines “learn”, through large training datasets. We investigate “one-shot” learning behaviours in mice in an attempt to uncover the hitherto unknown genetic and neuronal mechanisms. We evaluate how mice gather and aggregate sensory information from novel environments to optimise foraging and navigational strategies. Along this line of investigation, we also explore the cost-benefit estimations made by foraging mice as they balance their expenditure of energy so as to obtain nutrition and reward.  

Autonomic systems

The nervous system regularly functions beyond our cognitive control and without our realization. For example, respiratory rate, heart-rate, temperature homeostasis, metabolism, etc., are autonomic functions independent of our wilful control. These functions are critical for sustaining life and any interference with their function, for example brought about by ageing or disease, causes a range of neuropathies that can severely affect the quality of life. To identify critical neural centres for controlling the autonomic system and develop the technologies to do so we are currently generating high resolution anatomical and functional maps of the underlying neural circuitry. We then intend to stimulate these neural control centres to obtain a mechanistic understanding of how the autonomic system operates and control the autonomic system during ageing and disease to improve the quality of life.

Ryan Remedios, PhD

Principal Investigator, Autonomous and Autonomic Systems

Ryan Remedios brings a unique, integrative perspective to the field of neuroscience having started his career reverse engineering the self-organization of neural circuitry, then moving on to decoding how neurons control perception and cognition, and more recently unravelling the mechanisms underlying the formation of hardwired networks and behaviours. He has gained expertise with electrophysiological and optophysiological techniques for recording the activity of and controlling populations of single neurons, functional magnetic resonance imaging for identifying active brain networks, computational tools for the analyses of neuronal activity, and histological and molecular biological techniques for identifying and targeting specific types of neurons.
 

Factsheet

Ryan Remedios, PhD

Positions and Career

2018 - present
Principal Investigator Helmholtz Pioneer Campus, Helmholtz Zentrum München, Germany

2011 - 2018
Postdoc, California Institute of Technology (Caltech), USA

 

2005 - 2011
PhD, International Max Planck Research School & University of Tübingen, Max Planck Institute for Biological Cybernetics, Germany

2002 - 2005
M.Sc. Tata Institute of Fundamental Research, India

1999 - 2002
B.Sc. University of Mumbai

 

Invited Lectures
2018
International Symposium on Individuality, Kyoto, Japan

2018
Segerfalk Minisymposium 2018, Lund, Sweden

2017
Society for Neuroscience Annual Meeting- Neuroscience Minisymposium, Washington D.C., USA

2016
Bordeaux Neurocampus Brain Conference, France

2012
Francis Crick Memorial Conference, Cambridge, UK

 

Awards

2009
Athinoula A. Martinos Foundation award (from the European Brain and Behaviour Society)

2013
KGI Bioscience Management Bootcamp Scholarship

 

Samuel Adler

Robert Robertson

Selected Publications

Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex.

Remedios R, Kennedy A, Zelikowsky M, Grewe BF, Schnitzer MJ, Anderson DJ.
Nature. 2017 Oct 18;550(7676):388-392. doi: 10.1038/nature23885.

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Monkey drumming reveals common networks for perceiving vocal and nonvocal communication sounds.

Remedios R, Logothetis NK, Kayser C.
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):18010-5. doi: 10.1073/pnas.0909756106. 

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Unimodal responses prevail within the multisensory claustrum.

Remedios R, Logothetis NK, Kayser C.
J Neurosci. 2010 Sep 29;30(39):12902-7. doi: 10.1523/JNEUROSCI.2937-10.2010.

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An auditory region in the primate insular cortex responding preferentially to vocal communication sounds.

Remedios R, Logothetis NK, Kayser C.
J Neurosci. 2009 Jan 28;29(4):1034-45. doi: 10.1523/JNEUROSCI.4089-08.2009.

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A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.

Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, Hevner RF, Suda Y, Aizawa S, Ohshima T, Stoykova A, Tole S.
Nat Neurosci. 2007 Sep;10(9):1141-50.

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Contact us

HPC contact Remedios

Contact

 

Helmholtz Pioneer Campus
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Ingolstädter Landstr. 1
85764 Neuherberg
Germany