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Prof. Dr. Matthias Tschöp
Director of Biomedicine

Early in my career, I reported on the orexigenic, adipogenic, and metabolic effects of ghrelin. This groundbreaking discovery added a fundamental pathway to the model of body weight and glucose control and established a novel set of drug targets for the treatment of the metabolic syndrome. Together with my close collaborator Richard DiMarchi I went on to dissect gut-brain communication pathways, based on GI-hormone signaling and lessons from unraveling the molecular underpinnings of gastric bypass surgery. Together with Richard DiMarchi, we recently discovered yet another class of novel drug candidates by engineering peptide based steroid/small molecule delivery to selected cell populations. Several of the above described gut hormone-based single molecule combinatorial therapeutics are now in clinical development for the treatment of diabetes and obesity.

Factsheet
Prof. Dr. Matthias Tschöp

Positions and Career

2018-present
Chief Executive Officer and Scientific Director, Helmholtz Zentrum München

2016-present
Director of Biomedicine, Helmholtz Pioneer Campus, Helmholtz Zentrum München

2012-present
Adjunct Professor, Yale University

2012-present
Alexander von Humboldt Professor and Chair, Division of Metabolic Diseases
Professor of Medicine, Technical University of Munich

2011-2018
Scientific Director, Helmholtz Diabetes Center
Director, Institute for Diabetes and Obesity, Helmholtz Zentrum München

2009-2011
Arthur Russell Morgan Endowed Chair of Medicine, College of Medicine, University of Cincinnati

2009-2011
Research Director, Cincinnati Diabetes and Obesity Center, College of Medicine, University of Cincinnati

2009-2011
Professor (Assoc. since 2003; tenure since 2007), Institute for Metabolic Disease, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati

2002-2003
Senior Scientist, Department of Pharmacology, German Institute of Human Nutrition, Potsdam-Nuthetal, Germany

1999-2002
Postdoctoral Scientist, Discovery Research (Nature 2000. Cit.: 4080), Lilly Research Laboratories, Eli Lilly and Co., Indianapolis

1995-1999
Research Fellow, Neuroendocrine Unit, Ludwig-Maximilian University of Munich, Innenstadt University Hospital

1995-1999
Resident, Department of Internal Medicine, Ludwig-Maximilian University of Munich, Innenstadt University Hospital

 

2018
Avira Programme, INSEAD Business School, Fontainebleau, France

1998
Ludwig Maximilian University, Munich (Germany), “Magna Cum Laude”, Dr. med.

1994
Ludwig Maximilian University, Munich (Germany), graduation from medical school

1987-1994
Ludwig Maximilian University, Munich (Germany), pre-medical and medical school, internship in internal medicine, surgery and psychiatry

 

2018
Preis für interdisziplinäre Zusammenarbeit 2016/2017 des Vereins der Freunde und Förderer des Helmholtz Zentrum München für das paper: „Identification of proliferative and mature β-cells in the islets of Langerhans“

2018
Ordinary member of the Bavarian Academy of Sciences and Humanities

2018
Carus Prize, City of Schweinfurt. Awarded since 1896 in recognition of important scientific discoveries 

2017
Charles H. Best Lectureship and Award of the University of Toronto

2017
Carus Medal of the National Academy of Sciences (Leopoldina)

2017
Rolf-Sammet-Guest Professorship at Frankfurt University

2017
Geoffrey Harris Prize of the European Society of Endocrinology

2017
Hansen Family Award, Bayer Foundations

2017
Honorary doctorate (Dr. h.c.), University of Leipzig

2017
Endocrine Society Outstanding Innovation Award

2016
Elected Member, Academia Europaea (AE)

2016
European Research Council (ERC) Advanced Grant (AdG). Project Acronym: HypoFlam, Project: Targeting hypothalamic inflammation in obesity and diabetes; HI: HMGU, 2016-2021

2016
The Victor Mutt Award of the International Regulatory Peptide Society. The award goes to an outstanding researcher within the field of regulatory peptides

2016
European Medal of the Society for Endocrinology

2014
Erwin Schrödinger Prize, Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren

2014
Paul Martini Prize of the Paul Martini Foundation

2014
Gill Distinguished Scientist Award of Indiana University

2014
Journal of Peptide Science - Best Paper Award

2013
Elected Member, German National Academy of Sciences (Leopoldina)

2012
Werner Creutzfeldt Award of the German Diabetes Society

2012
Alexander von Humboldt Professorship

2011
Outstanding Scientific Achievement Award, American Diabetes Association

2010
NIH/NIDDK 60th Anniversary Scholar Award

2010
André Mayer Award, Int. Association for the Study of Obesity (IASO)

2009
Elected Member, The American Society for Clinical Investigation (ASCI)

2007
Outstanding Scientific Achievement Award, The Obesity Society (TOS)

2007
Christina Barz Award of the German Society for Psychiatry, Neurology and Psychosomatic Medicine

2002
Young Investigator Award, European Neuroendocrine Association (ENEA)

2001
Schoeller-Junkmann Award of the German Endocrine Society (DGE)

2000
Lilly Research Laboratories President’s Award

2000
Eli Lilly Endocrine Research Award for Science

 

German National Academy of Sciences (Leopoldina)
Academia Europaea (AE)
American Diabetes Association (ADA)
American Society for Clinical Investigation (ASCI)
European Association for the Study of Diabetes (EASD)
European Society of Endocrinology (ESE)
German Diabetes Society (DDG)
German Endocrine Society (DGE)
Society for the Study of Ingestive Behavior (SSIB)
The Endocrine Society (ES)
The European Neuroendocrinology Association (ENEA)
The Obesity Society (TOS)

 

Selected Publications

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Clemmensen C, Jall S, Kleinert M, Quarta C, Gruber T, Reber J, Sachs S, Fischer K, Feuchtinger A, Karlas A, Simonds SE, Grandl G, Loher D, Sanchez-Quant E, Keipert S, Jastroch M, Hofmann SM, Nascimento EBM, Schrauwen P, Ntziachristos V, Cowley MA, Finan B, Müller TD, Tschöp MH.
Nat Commun. 2018 Oct 23;9(1):4304. doi: 10.1038/s41467-018-06769-y. 
 

More Details

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.
Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. 

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Astrocytic Insulin Signaling Couples Brain Glucose Uptake  with Nutrient Availability.

García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH.
Cell. 2016 Aug 11;166(4):867-880. doi:10.1016/j.cell.2016.07.028.

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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH.
Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761.

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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.
Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.

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Targeted estrogen delivery reverses the metabolic syndrome.

Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, de Angelis MH, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH.
Nat Med. 2012 Dec;18(12):1847-56. doi:10.1038/nm.3009.

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Melanocortin signaling in the CNS directly regulates circulating cholesterol.

Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp MH.
Nat Neurosci. 2010 Jul;13(7):877-82. doi: 10.1038/nn.2569.

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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E,  Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.
Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209.

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GOAT links dietary lipids with the endocrine control of energy balance.

Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schürmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschöp MH.
Nat Med. 2009 Jul;15(7):741-5. doi: 10.1038/nm.1997.

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Ghrelin induces adiposity in rodents.

Tschöp M, Smiley DL, Heiman ML.
Nature. 2000 Oct 19;407(6806):908-13. doi: 10.1038/35038090

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